解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The purpose of this study was to determine the performance characteristics of the Cozart Methadone Microplate ELISA assay for the detection of methadone and methadone metabolites in hair specimens. One hundred and ten hair specimens were collected from volunteers (n=46) with a history of drug use and from drug-related...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.7.678
更新日期:2005-10-01 00:00:00
abstract::A woman was alleged to have committed suicide by consuming a gasoline additive shortly before jumping from a second floor balcony within her home. She was found dead by police with a multitude of injuries, lying nude in a partially evaporated unknown residue that was later determined to be methanol. Samples collected ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.7.734
更新日期:2005-10-01 00:00:00
abstract::In preparation for a treatment program concerning the medical coprescription of heroin and methadone to treatment-resistant addicts in the Netherlands, we studied a novel strategy for monitoring co-use of illicit (nonprescribed) heroin. A deuterated analogue of heroin was added (1:20) to pharmaceutical, smokable heroi...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.6.564
更新日期:2005-09-01 00:00:00
abstract::This study identified ethyl sulfate (EtS) in human urine and compared the excretion characteristics of EtS with that of ethanol and ethyl glucuronide (EtG). Urine samples were collected from healthy subjects after a single ethanol dose, and also selected from routine clinical samples. Simultaneous analysis of EtS and ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.5.270
更新日期:2005-07-01 00:00:00
abstract::The abuse of the designer amphetamines such as 3,4-methylenedioxymethamphetamine (MDMA) is increasing throughout the world. They have become popular drugs at all night techno dance parties, and their detection is an important issue. The objective of the presented study was to identify an unknown compound detected by t...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.5.353
更新日期:2005-07-01 00:00:00
abstract::A case report involving a 34-year-old white male who was found dead at home by his roommate is presented. At the time of his death, he was being treated with tramadol/acetaminophen, metaxalone, oxycodone, and amitriptyline. The decedent's mother stated that he had been taking increasing amounts of pain medication in o...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.5.401
更新日期:2005-07-01 00:00:00
abstract::The aim of this study was to investigate the early-phase postmortem redistribution of the enantiomers of citalopram (CIT) and its metabolites demethylcitalopram (DCIT) and didemethylcitalopram (DDCIT) in a rat model. Furthermore, we wanted to examine the role of the lungs as a reservoir of postmortem drug release and ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.4.223
更新日期:2005-05-01 00:00:00
abstract::A fast and efficient multiresidue extraction-purification procedure was developed for low levels (ppb range) of phenanthrene and hydroxyphenanthrene in biological matrices, in order to quantify phenanthrene and metabolites in blood, milk, urine, and biological tissues of lactating goats. Detection and identification o...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.3.175
更新日期:2005-04-01 00:00:00
abstract::As an approved medicinal product and reportedly an abused substance that have been associated with death and "considered to be a factor...of impaired driving, sexual assault, and other violent crimes", triazolam is controlled at the same level (Level III) as flunitrazepam in Taiwan. Alleged misuses of this substance h...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.2.118
更新日期:2005-03-01 00:00:00
abstract::A liquid chromatographic method for the determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine and male and female B6C3F1 mouse urine was developed for use in supporting toxicokinetic studies, validated, and used to analyze urine samples for a preliminary dose level range-find...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/29.1.28
更新日期:2005-01-01 00:00:00
abstract::A quantitative analysis was developed for the determination of cocaine, benzoylecgonine, and cocaethylene in oral fluid using liquid chromatography-tandem mass spectrometry. After internal standardization and solid-phase extraction, chromatographic separation was achieved on a reversed-phase column by gradient elution...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.8.655
更新日期:2004-11-01 00:00:00
abstract::Six separate methods to detect oxidants in urine were developed. The presence of the oxidants was established by initial oxidation of ferrous to ferric ion and detecting the ferric by chromogenic oxidation or complex formation. The reagents for chromogenic oxidation were N,N-dimethylamoino-1,4-phenylenediamine (DMPDA)...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.7.599
更新日期:2004-10-01 00:00:00
abstract::A study of the urinary concentration of fentanyl (F) and its major metabolite norfentanyl (NF) in chronic pain patients treated with the Duragesic continuous release transdermal patches is presented. These patches are available in 10, 20, 30, and 40 cm(2) sizes releasing 25, 50, 75, and 100 microg/h F, respectively. F...
journal_title:Journal of analytical toxicology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/jat/28.6.422
更新日期:2004-09-01 00:00:00
abstract::A new point-of-care colloidal metal immunoassay urine drugs-of-abuse testing device, the BIOSITE TRIAGE Plus Propoxyphene (TPP), was evaluated for the rapid detection of dextropropoxyphene (PPY) and/or its primary metabolite, norpropoxyphene (NP), in urine at a total PPY/NP concentration of 300 ng/mL or greater. This ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.6.485
更新日期:2004-09-01 00:00:00
abstract::We report a case involving unusually high postmortem morphine concentrations in a 44-year-old male with end-stage pancreatic cancer. He was receiving morphine for pain control via a single subclavian intravenous catheter. Allegations of foul play were made by family members at the time of death, so a full autopsy was ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.6.529
更新日期:2004-09-01 00:00:00
abstract::The nitrogen mustards bis(2-chloroethyl)ethylamine (HN1), bis(2-chloroethyl)methylamine (HN2), and tris(2-chloroethyl)amine (HN3) have the potential to be used as chemical terrorism agents because of their extreme vesicant properties. We modified a previously reported method to incorporate automated solid-phase extrac...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.5.320
更新日期:2004-07-01 00:00:00
abstract::British anti-Lewisite (BAL) (2,3-dimercapto-1-propanol) is a potential therapeutic compound when used against the effects of cutaneous sulfur mustard, and a method for its determination in plasma has been developed. BAL and the internal standard (IS) ethane dithiol were isolated from plasma samples through solid-phase...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.5.384
更新日期:2004-07-01 00:00:00
abstract::Improvements have been made in recent years in on-site or point-of-care (POC) immunoassay testing devices. We evaluated the DrugCheck 9 cup, a new qualitative visually read, competitive binding, immunoassay cup that measures nine analytes. The study was performed according to the recent National Laboratory Certificati...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.3.190
更新日期:2004-04-01 00:00:00
abstract::The aim of this study was to develop, optimize, and validate an analytical procedure to determine a group of eight amphetamines, amphetamine (AMP), ephedrine (EP), methcathinone (MTC), paramethoxyamphetamine (PMA), methamphetamine (MA), methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and methyle...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.2.77
更新日期:2004-03-01 00:00:00
abstract::This paper presents a case of fatal overdosage due to an accidental massive administration (750 mg instead of 170 mg) of cisplatin, an anticancer agent, to a 63-year-old patient suffering from lymphoma. Platinum was measured in various postmortem samples by means of inductively coupled plasma mass spectrometry. Heart ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.2.138
更新日期:2004-03-01 00:00:00
abstract::Analysis and interpretation of the findings for the drug of abuse gamma hydroxybutyric acid (GHB) in fatalities has become very problematic. This is primarily because of variable data in postmortem biological fluids resulting from the endogenous nature of the compound, possible postmortem production, and varying metho...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/28.1.20
更新日期:2004-01-01 00:00:00
abstract::First synthesized in 1970, propafenone is a frequently used 1C antiarrhythmic drug metabolized into two major metabolites, 5-hydroxypropafenone and norpropafenone. Paradoxically, fatal intoxication is rarely described, and only six cases have been reported in the literature. We report our experience with two patients ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.8.595
更新日期:2003-11-01 00:00:00
abstract::A rapid and sensitive solid-phase extraction method for the lysergic acid diethylamide (LSD) metabolite 2-oxo-3-hydroxy-LSD (O-H-LSD) was developed for use in a forensic laboratory. The method uses a positive-pressure manifold anion-exchange polymer-based solid-phase extraction with subsequent analysis by liquid chrom...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.7.459
更新日期:2003-10-01 00:00:00
abstract::Caffeine is the world's most widely consumed drug with its main source found in coffee. We evaluated the caffeine content of caffeinated and decaffeinated specialty coffee samples obtained from coffee shops. Caffeine was isolated from the coffee by liquid-liquid extraction and analyzed by gas chromatography with nitro...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.7.520
更新日期:2003-10-01 00:00:00
abstract::Acetaminophen (APAP, n-acetyl-p-aminophenol) and salicylate (ASA, acetylsalicylic acid) are two of the most frequently overdosed drugs reported in the emergency room. Most APAP and ASA tests are performed with analytical instruments in laboratories, which are not always ideal for emergency situations. A rapid membrane...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.6.366
更新日期:2003-09-01 00:00:00
abstract::Baclofen (Lioresal), a lipophilic analogue of c-aminobutyric acid (GABA), and carisoprodol (Soma), a central nervous system depressant with an unknown mechanism of pharmacologic action, are categorized as muscle relaxants. Baclofen is used clinically in the management of spasticity and its sequelae secondary to severe...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.5.275
更新日期:2003-07-01 00:00:00
abstract::We report one fatal case of asphyxia caused by leaves of common ivy. Macroscopic examination of the corpse during the autopsy disclosed an incredible quantity of leaves of Hedera helix in the mouth and throat of the decedent. In order to rule out the possibility of poisoning by the toxic saponins contained in the plan...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.4.257
更新日期:2003-05-01 00:00:00
abstract::A method for the determination of seven polychlorinated biphenyl residues in plasma by gas chromatography-mass spectrometry was developed. The analytes were isolated from human plasma by liquid-liquid extraction, followed by solid-phase extraction, and separation on an HP5 Trace column. Ionization mode was electronic ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.2.74
更新日期:2003-03-01 00:00:00
abstract::Separating drugs which are both polar and basic has long been difficult because of the limited operating pH range of conventional HPLC columns. This paper describes a liquid chromatographic method capable of being used with either diode-array or mass spectrometric detection for the identification and quantitation of 1...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/27.1.30
更新日期:2003-01-01 00:00:00
abstract::Draft guidelines for the use of oral fluid for workplace drug testing are under development by the Substance Abuse and Mental Health Services Administration (SAMHSA) in cooperation with industry and researchers. Comparison studies of the effectiveness of oral fluid testing versus urine testing are needed to establish ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.8.541
更新日期:2002-11-01 00:00:00
abstract::The relationship between blood cocaine concentrations and pharmacological effects is of both theoretical and practical interest. This study utilized a computer-assisted smoking device for the delivery of three active doses (10, 20, and 40 mg) of cocaine base to seven human volunteers. Doses were administered in an asc...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.7.382
更新日期:2002-10-01 00:00:00
abstract::Bleach, nitrite, chromate, and hydrogen peroxide-peroxidase are effective urine adulterants used by the illicit drug users to conceal marijuana-positive results. Methods for detecting nitrite and chromate are available. Effects of other oxidizing agents that could possibly be used as adulterants and are difficult to d...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.7.460
更新日期:2002-10-01 00:00:00
abstract::In an effort to determine a practical, efficient, and economical alternative for the use of a radioimmunoassay (RIA) for the detection of lysergic acid diethylamide (LSD) in human urine, the performance of two photometric immunoassays (Dade Behring EMIT II and Microgenics CEDIA) and the Diagnostics Products Corp. (DPC...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.7.519
更新日期:2002-10-01 00:00:00
abstract::There have been numerous reports of lead poisoning resulting from the ingestion of foreign bodies. A case involving the ingestion of spent air rifle pellets is described. No clinical symptoms were observed, despite the fact that the young child exhibited elevated blood lead levels as high as 2.7 micromol/L (56 microg/...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.6.370
更新日期:2002-09-01 00:00:00
abstract::Human exposure to organophosphate pesticides can be estimated from the presence of urinary metabolites. An isotope-dilution gas chromatography-tandem mass spectrometry (GC-MS-MS) method was developed for quantitating the six dialkyl phosphate urinary metabolites of at least 29 organophosphate pesticides. Urine samples...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.5.245
更新日期:2002-07-01 00:00:00
abstract::An online automatic sample cleanup system was developed for use with electrospray ionization tandem mass spectrometry (ESI-MS-MS) for the quantitative detection of the benzene exposure biomarker S-phenylmercapturic acid (S-PMA) in human urine. The sample clean-up system was constructed with an autosampling device, a r...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.4.205
更新日期:2002-05-01 00:00:00
abstract::An original high-performance liquid chromatographic-mass spectrometric (HPLC-MS) procedure was developed for the determination of cyanide (CN) in whole blood. After the addition of K13C15N as internal standard, blood was placed in a microdiffusion device, the inner well of which was filled with a mixture of taurine (5...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.3.144
更新日期:2002-04-01 00:00:00
abstract::An automated column-switching liquid chromatographic-atmospheric pressure chemical ionization-mass spectrometric (LC-APCI-MS) method for the simultaneous determination of frequently encountered benzodiazepine hypnotics and their relevant metabolites in urine has been established. A column-switching online solid-phase ...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.2.87
更新日期:2002-03-01 00:00:00
abstract::An isotope dilution gas chromatography-tandem mass spectrometric (GC-MS-MS) method was developed for quantitating the urinary metabolites of the organophosphorus nerve agents sarin, soman, tabun (GA), VX, and GF. Urine samples were concentrated by codistillation with acetonitrile, derivatized by methylation with diazo...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/26.1.6
更新日期:2002-01-01 00:00:00
abstract::In this study, we investigated the effectiveness of the Roche Kinetic Interaction of Microparticles in Solution (KIMS) screening assay for cannabinoid metabolites. Urine specimens (N = 1689) were collected during elimination of cannabinoids from 25 subjects with a history of marijuana use. Specimens were analyzed conc...
journal_title:Journal of analytical toxicology
pub_type: 杂志文章
doi:10.1093/jat/25.7.559
更新日期:2001-10-01 00:00:00